Charlotte and Dr. Vargas met years ago as they worked together on a new car model. They fell in love with each other as they contiuned to work together in the study of the ancient relics and other projects. During an underground expedition for the ancient relics 20 years ago, they uncovered a mysterious relic orb that was unique from the others. However, an earthquake occurred that resulted in Charlotte falling into a deep crevasse. Despite Dr. Vargas searching for her for weeks, not a trace of Charlotte was found and she was presumed dead. One of Viktor's comments during the story implied that Charlotte "domesticated" him, suggesting that Charlotte had a major influence on the kind of person that the Doctor is today. There was even a statue that was erected in the doctor's garden in remembrance of her.
It wouldn't be until the Goblins' attacks with new advance weaponry, that Dr. Vargas finds his way to discovering that she was indeed still alive. She was however spiteful towards the Doctor, believing that he had left her to die years ago. She was apparently found by the goblins and nursed back to health except needing a cane to walk now. At that time, the leader of the Goblins, Gundahar asked for her help in creating better weapons, armour and war vehicles to fend off his enemy tribes. A form of mutual bond seemed to had developed between her and Gundahar as she was eventually welcomed into the Goblin tribes. When she learned that Gundahar started to use her creations against her race, she stopped developing new weapons for him. She at first chose against returning with the heartbroken Dr. Vargas but after having a falling out argument with Gundahar and learned that he was only using her to destroy humanity, she uses a holo-bot given to her by the Doctor to contact him to save her. When Dr. Vargas returned for her, she meets Lucus and Knack for the first time. She gives them her last work for Gundahar, an aircraft to fly after Viktor for the relic key. She, along with other three witness the "great transformation" that Viktor unlocked as they flew back to Trodgo Mine. The aircraft gets shot down but crashes safely. She stands by with Dr. Vargas and Lucus as Knack goes to successfully take out the giant relic orb responsible.
She is later standing on a parade float with the Doctor and Lucus, waving to the cheering crowd. Also she witness the award medals ceremony on-stage with the three.